Chlorothiazide to hydrochlorothiazide conversion

In hypertension trials, doses of 12.5 - 25 mg/day were typically used In general, a 12.5mg dose of chlorthalidone is equivalent to 25mg of hydrochlorothiazide. See HCTZ vs Chlorthalidone for more. Doses above 50mg/day are rarely used and may lead to significant hypokalemi chlorothiazide and hydrochlorothiazide. These agents are often used in combination with loop diuretics or spironolactone in the management of infants with pulmonary edema associated with RDS or BPD. Reported adverse effects of the thiazides include hyperuricemia, hypersensitivity reactions, cholestasis, muscle cramps, dizziness, nausea, and. Reference: Dhalla IA, Gomes T, Yao Z, et al. Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. Ann Intern Med . 2013.

Are Chlorthalidone and Hydrochlorothiazide Equivalent Blood-Pressure-Lowering Medications? Nitin Khosla MD, From the Department of Preventive Medicine, Rush Hypertension/Clinical Research Center, Rush University Medical Center, Chicago, IL. Search for more papers by this author A comparison of hydrochlorothiazide and chlorothiazide in the treatment of hypertension has been attempted in seventy-two patients. In sixty patients with essential hypertension, who were receiving chlorothiazide as well as various antihypertensive agents, hydrochlorothiazide was substituted for chlorothiazide hydrochlorothiazide combination (-29.5 mm Hg, mean difference -5.6 mm Hg, P < .001). Meta-analyses also support the conclu-sion that chlorthalidone is more potent than hydrochlorothiazide in lowering blood pres-sure.35,36 Several studies have shown that chlorthalidone at the same dose is 1.5 to 2 times as potent as hydrochlorothiazide.33,36,3 Chlorthalidone is an oral diuretic with prolonged action (48-72 hours) and low toxicity. The major portion of the drug is excreted unchanged by the kidneys. The diuretic effect of the drug occurs in approximately 2.6 hours and continues for up to 72 hours. The mean half-life following a 50 to 200 mg dose is 40 hours

Chlorothiazide Sodium for Injection, USP is a dry, sterile lyophilized powder, supplied as follows: 500 mg/vial - Packaged individually. Vial stoppers do not contain natural rubber latex. Storage Store lyophilized powder between 2 and 25°C (36 and 77°F). For single dose only. Use solution immediately after reconstitution Chlorothiazide Drug Class: Diuretics Forms: Tablet, Suspension, IV Tablet Formulations: 250 mg, 500 mg IV Solution Formulations: 500 Oral Suspension: 250 mg/5 mL Hydrochlorothiazide Drug Class: Diuretics Forms: Tablet, Capsule, Suspension Tablet Formulations: 25 mg, 50 mg, 100mg Capsule Formulations: 12. Chlorothiazide is contraindicated in patients with anuria. Like other diuretics, chlorothiazide, should be used with caution in patients with severe liver disease. The possible electrolyte and intravascular fluid shifts associated with chlorothiazide-induced diuresis has resulted in hepatic coma and death in some patients with hepatic cirrhosis. Hydrochlorothiazide: VS: Chlorothiazide: Add another Item to this comparison Add Item. Overview: There are 16 differences and 4 similarities between Hydrochlorothiazide, Chlorothiazide . All attributes Differences Similarities. Basic Medical Information; Common Brand Name Esidrix, Hydrodiuril, Microzide Two to three times as potent as Hydrochlorothiazide Conversion: Use 12.5 mg of Chlorthalidone in place of 25 mg Hydrochlorothiazide Monitor Serum Potassium at baseline, 2 weeks and every 6-12 months (increased Hypokalemia risk

Thiazide diuretic dosing chart - Straight Healthcar

Guidelines for Use of Chlorothiazide (Diuril) ) Recommended Neonatal Dose, Route, and Interval Diuresis: 10-20 mg/kg/dose PO every 12 hours Chief Indications 1. Diuretic used to treat both mild to moderate edema and mild to moderate hypertension 2. May improve pulmonary function in patients with BPD 3 Hydrochlorothiazide and chlorthalidone have been the 2 most commonly used diuretics in major clinical trials. Treatment guidelines and compendia often consider these 2 drugs interchangeable agents within the class of thiazide or thiazide-like diuretics. Many sources list them as equipotent. Despite these beliefs, there is some suggestion that. A very important difference is the extremely long half-life of 40 to 60 hours for chlorthalidone, in the other hand hydrochlorothiazide has a much shorter but wider variation in half-life, from 3 to 13 hours. If you use doses of chlorthalidone greater than 25 mg the benefit for BP reduction is limited. If higher doses of chlorthalidone are. 300+ CE courses, including the popular CE-in-the-Letter. Quick reference drug comparison charts. Access to the entire archive Some experts consider doses of 50 mg or less to be compatible with breast-feeding. In general, the use of bendroflumethiazide, chlorthalidone, chlorothiazide, and hydrochlorothiazide has been considered usually compatible with breast-feeding by the American Academy of Pediatrics, due to lack of noted adverse effects on the nursing infant

Same Benefit with Equivalent Doses of Chlorthalidone and

Chlorothiazide 250 mg tablet Diuril Hydrochlorothiazide 25 mg Chlorothiazide 500 mg tablet Diuril Hydrochlorothiazide 50 mg Methyclothiazide 2.5 mg Hydrochlorothiazide 12.5 mg Methyclothiazide 5 mg Hydrochlorothiazide 25 mg Trichlormethiazide 1 mg Hydrochlorothiazide 25 mg Trichlormethiazide 2 mg Hydrochlorothiazide 50 m Original Article from The New England Journal of Medicine — A Comparison of the Side Effects and Antihypertensive Potency of Chlorothiazide and Hydrochlorothiazide logo-32 logo-4

DESCRIPTION: Hydrochlorothiazide is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. It is chemically designated as 6­ chloro-3,4-dihydro-2 H-1,2,4-benzothiadiazine-7-sul­ fonamide 1,1-dioxide and has the following structural formula: C7H8ClN3O4S2 M.W. 297.74 Hydrochlorothiazide, USP is a white, or practicall Chlorthalidone produces slightly greater reductions in blood pressure compared with hydrochlorothiazide (HCTZ), but it is associated with greater declines in serum potassium levels. Chlorthalidone. From 1 March, 2020: cilazapril with hydrochlorothiazide will no longer be available funded for patients that have never been prescribed this medicine before. Prescribers should ensure no new patients are started on this medicine from 1 March, 2020. Prescribers will need to endorse * any prescriptions for patients who were taking this medicine.

When the serum creatinine level exceeds 2 mg/dL (to convert to micromoles per liter, multiply by 88.4) (or a glomerular filtration rate <50 mL/min), the thiazide-type diuretic may become ineffective, and a loop diuretic should be used instead, both as a diuretic and as a BP-lowering agent Thiazide diuretics (Chlorothiazide, hydrochlorothiazide) Aside from the usual diuretic symptoms, this drug class can cause hypokalemia and metabolic acidosis, potentiation of anesthetics and cardiac glycosides, worsen impaired hepatic function, and derange glucose/insulin balances of diabetic patients Elizabeth A. Jackson, MD, FACC. Results: A total of 730,225 adults (mean age 51.5 years, 450,100 women [61.6%]) were included in the present analysis, of which 36,918 were dispensed or prescribed chlorthalidone and 693,337 were dispensed or prescribed HCTZ Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent

Three simple, sensitive, and validated methods were developed for the quantitative determination of fosinopril sodium (FOS) and hydrochlorothiazide (HCZ) in the presence of an HCZ impurity, chlorothiazide (CZ). The first method (I) was the ratio difference spectrophotometric method (RD), in which a standard spectrum of 8 μg mL-1 HCZ was used as a divisor, and the difference in amplitude. The results showed an increase of urine output 24 hours after a dose of oral hydrochlorothiazide or IVCTZ. However, IVCTZ produced a greater urine output compared to the oral hydrochlorothiazide. The authors recommended The authors concluded chlorothiazide conversion (CHLOROTHIAZIDE) ORAL SUSPENSION DESCRIPTION DIURIL * (Chlorothiazide) is a diuretic and antihypertensive. It is 6-chloro-2. H-1,2,4-benzothiadiazine­ 7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6ClN3O4S2 and its structural formula is: It is a white, or practically white, crystalline powder with a molecular weight of 295.72, which. Chart: ACEI, ARB, and Aliskiren Comparison June 2016. FAQ: FAQ: Rescheduling of Hydrocodone Combination Products October 2014. Chart: Comparison of Bupropion Products December 2012. Chart: Fentanyl Products for Breakthrough Pain October 2011. Other: FDA Drug Info Rounds—Drug Shortages (December 2010) August 2011. 1 This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect. The mean blood pressure-lowering effect over the dose range 6.25 mg, 12.5 mg, 25 mg and 50 mg/day is 4/2 mmHg, 6/3 mmHg, 8/3 mmHg and 11/5 mmHg, respectively

Are Chlorthalidone and Hydrochlorothiazide Equivalent

Chlorthalidone is better at lowering the risk of a cardiovascular event, such as a heart attack. Even after chlorthalidone and HCTZ achieve the same blood pressure, chlorthalidone lowers the risk of a cardiovascular event by about 20% more than HCTZ. Chlorthalidone reduces the size of the left ventricle wall more than HCTZ does DIURIL (chlorothiazide) is not metabolized but is eliminated rapidly by the kidney. The plasma half-life of chlorothiazide is 45-120 minutes. After oral doses, 10-15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk Uses. This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Hydrochlorothiazide belongs to a class of drugs. In a double-blind crossover study, the effectiveness of furosemide, 40 mg twice daily, was compared with hydrochlorothiazide, 50 mg twice daily, in hypertensive patients. Both hydrochlorothiazide and furosemide significantly reduced blood pressure (BP) during three months of therapy. However, the..

Chlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to. We describe a liquid-chromatographic procedure for detection in urine of all thiazide drugs currently used clinically. Urine is treated initially with NaBH4 to convert any chlorothiazide present to hydrochlorothiazide. The urine is acidified with NaH2PO4 (1.0 mol/L, pH 5), and.. Chlorothiazide a 500 mg was reconstituted with 18 mL of bacteriostatic water for injection, b resulting in a final concentration of 28 mg/mL. Next, 3.57 mL of the chlorothiazide solution was added to 1 mL of furosemide injection c (20 mg/2 mL), and 5% dextrose was added to attain a final volume of 10 mL. All compounds were used prior to expiration Chlorothiazide is a water pill ( diuretic) that causes you to make more urine. This helps your body get rid of extra salt and water.This medication is also used to decrease swelling ( edema. Losartan. Upsides: Losartan (Cozaar) was the first ARB to ever be approved, so it has the longest track record of success.; Losartan is available as a very affordable generic. Losartan is made as a stand-alone drug, and in a combination tablet with the diuretic, hydrochlorothiazide (HCTZ), as losartan/HCTZ.Convenient

Determination of 8 Diuretics and Probenecid in Human Urine

A comparison of hydrochlorothiazide and chlorothiazide in

Ibrahim A. Naguib, Eglal A. Abdelaleem, Hala E. Zaazaa, Mohammed E. Draz, Simultaneous Determination of Hydrochlorothiazide and Benazepril Hydrochloride or Amiloride Hydrochloride in Presence of Hydrochlorothiazide Impurities: Chlorothiazide and Salamide by HPTLC Method, Journal of Chromatographic Science, Volume 53, Issue 1, January 2015. We describe a liquid-chromatographic procedure for detection in urine of all thiazide drugs currently used clinically. Urine is treated initially with NaBH4 to convert any chlorothiazide present to hydrochlorothiazide. The urine is acidified with NaH2PO4 (1.0 mol/L, pH 5), and thiazides are extracted with ethyl acetate. Interfering substances are then removed in two washes with 0.1 mol/L. original article The new england journal of medicine n engl j med 349;17 www.nejm.org october 23, 2003 1628 Absence of Cross-Reactivity between Sulfonamide Antibiotics and Sulfonamid

ure the peak responses. Calculate the percentage of each impu-lated compound A, 0.8 for chlorothiazide, and 1.0 for hydro-rity in the portion of Hydrochlorothiazide taken by the formula:chlorothiazide; the resolution, R, between benzothiadiazine re-lated compound A and chlorothiazide is not less than 2.0 and 100(ric / Start studying 206 Exam 4 medications to know!!!!. Learn vocabulary, terms, and more with flashcards, games, and other study tools Lasix is an anthranilic acid derivative that is a type of loop diuretic while thiazides are another class of diuretic. A difference is that loop diuretics are more potent than thiazides. Examples of thiazides include chlorothiazide ( Diuril ), chlorthalidone (Hygroton), indapamide ( Lozol ), hydrochlorothiazide (Hydrodiuril), methyclothiazide.

Diuretics - GlobalRP

  1. Irbesartan and Hydrochlorothiazide Milpharm 300 mg/ 12.5 mg film-coated tablets
  2. ation of potassium in the urine), which causes abnormal cardiac rhythms The most common symptom associated with hypokalemia is muscle weakness.Patients receiving indapamide may need potassium supplements to prevent hypokalemia. . Hypomagnesemia (low blood magnesium) also ma
  3. imize dose-independent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with.
  4. Hydrochlorothiazide is a diuretic that treats water retention by reducing the amount of salt absorbed by the body. This is especially important in..
  5. D is generally well tolerated in recommended Adequate Intake (AI) doses. One study found a greater likelihood of daytime sleepiness for patients given vita
  6. Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke.

Dilution Chlorothiazide - GlobalRP

  1. The patient's meds included hydrochlorothiazide as the diuretic. We only carry Lasix on the truck. it came to diuresis I was a bit stuck. Even though I know what hydrochlorothiazide was...I didn't know if there was a conversion type dose vice standard dose of Lasix. I was honest and stated that while I wasn't sure I would call the on duty.
  2. e + magnesium carbonate. use alternative or monitor urine pH, especially if frequent or high-dose antacid use: combo may decr. methena
  3. Hypomagnesemia occurs with thiazide diuretics (chlorothiazide, hydrochlorothiazide, indapamide, and metolazone). Low serum magnesium may lead to serious adverse events such as muscle spasm, seizures, and arrhythmias. Therefore, clinicians should monitor serum magnesium concentrations periodically in patients taking a PPI and diuretics.
  4. e hippurate) +. potassium citrate. 1 interaction. Avoid/Use Alternative. methena
  5. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure. Lowers blood pressure. Removes extra water from your body. Thalitone (chlorthalidone) is a well-tolerated water pill that's increasingly used to treat high blood pressure

inform patients taking hydrochlorothiazide-containing products of the cumulative, dose-dependent increased risk of non-melanoma skin cancer, particularly in long-term use, and advise patients to regularly check for and report any new or changed skin lesions or moles; advise patients to limit exposure to sunlight and UV rays and use adequate sun. · Chlorothiazide Hydrochlorothiazide. Hypertension Edema Renal Failure Sequential nephron blockade. Opioid Analgesics · Phentanylcitrate · Morphine Conversion math. 10 terms. jovanalizbeth PLUS. Medication Suffixes. 38 terms. jovanalizbeth PLUS. OTHER QUIZLET SETS. Manf 351 Product and Process Design Final. 109 terms Is there specific healthcare software that would benefit from using DrugBank? Let us know Some water pills include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. Curly parsley is darker than the flat-leaf variety, and has a milder taste

No difference in conversion to SR Chlorothiazide 125 500 1.5 $7.56 -20.77 (no) Hydrochlorothiazide 12.5‐25 25 2.5 $2.52 ‐12.60. - Generic names - chlorothiazide; hydrochlorothiazide - Brand names - Diuril; HCTZ - Action • increases the excretion of Na+ and Cl-with a corresponding loss of H 2O by blocking Na+ and Cl-reabsorption by the distal renal tubules -Indications • associated with CHF, pts with hepatic cirrhosis and pts wit

Alternatives to Chlorothiazide - Comparica

Abstract. Simple, selective and sensitive high-performance thin layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of hydrochlorothiazide (HCZ) in the presence of its impurities (chlorothiazide (CT) and salamide (DSA)), in two quaternary mixtures with benazepril hydrochloride (BZ) or amiloride hydrochloride (AM) Amiloride/ hydrochlorothiazide (Moduretic) Depletions from potassium-sparing diuretics are discussed in this article. If you are taking any of these combinations, you may also want to consult the thiazide diuretics depletion article

Same as chlorothiazide; hypokalemia is major electrolyte imbalance: Footnotes. The plasma clearance of furosemide varies considerably in the neonate (Aranda et al 1980, Chemtob et al 1987). Since the diuretic effect occurs subsequent to renal tubular secretion, the excessive plasma concentration is more likely to result in displacement of. Hydrochlorothiazide belongs to a class of drugs known as diuretics that are prescribed to combat fluid retention and to lower blood pressure 1 5. The drug is also widely used to treat congestive heart failure, a condition in which the heart works less efficiently, causing the buildup of fluid in the lungs and elsewhere in the body Common agents include chlorothiazide, hydrochlorothiazide, and the thiazide-like diuretic metolazone. Adjunctive use of thiazides can overcome the resistance to loop diuretics associated with reactive hypertrophy of the distal convoluted tubule (DCT) of the nephron. By blocking the Na-Cl channel in the DCT, they hinder the avid sodium. Chlorothiazide also known by the brand name Diuril is a diuretic that helps rid your body of salt (sodium) and water. Chlorothiazide (Diuril) works by making your kidneys put more sodium into your urine. The sodium, in turn, takes water with it from your blood. That decreases the amount of fluid flowing through your blood vessels, which reduces. Diuretics - Thiazide Diuretics: Chlorothiazide, Hydrochlorothiazide, Indapamide, Methylclothiazide, Metolazone; Loop Diuretics Furosemide, Lasix, Ethacrynic Acid, Edecrin, Bumex signals your liver decrease T4 to T3 conversion in favor of T4 to rT3 conversion. Thyroid glandulars - natural desiccated thyroid - are considered to be a.

Chlorothiazide Dosage Guide + Max Dose, Adjustments

Nov 15, 1995 . Concurrent use of chlorothiazide has reportedly decreased. .hydrochlorothiazide in place of chlorothiazide, the difference in dosing of these.Aug 8, 2015 . HYDROCHLOROTHIAZIDE AND CHLORTHALIDONE but both contain a.chlorothiazide, which can lead to lower intra- cellular pH and cell volume.. .tagonists, ie, angiotensin-converting enzyme inhibitors, angiotensin II Hydrochlorothiazide (HCTZ) is a thiazide diuretic that works by increasing the amount of sodium, chloride, and water excreted in the urine. Other thiazide diuretics include chlorthalidone and chlorothiazide. Thiazide diuretics are commonly used for blood pressure management, but can also be used for its diuretic effects to reduce swelling or. Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in presence of their degradation products. Finally, the degradation products were characterized through.

Hydrochlorothiazide vs Chlorothiazide Hypertension Drugs

Hydrochlorothiazide. Treatment of mild to moderate HTN; treatment of edema in heart failure and nephrotic syndrome. A: ~50-80% M: minimal metabolism E: Urine t½ = 5.6-14.8 hrs. Rating B Enters breast milk, avoid use in lactation. Generic available. 12.5 mg: $0.42 25mg: $0.08 50mg: $0.16. Chlorothiazide. Management of mild to moderate HTN. Diuretic are another class of medications commonly used for the treatment of hypertension. One of the most common types of diuretics is hydrochlorothiazide (or HCTZ). Diuretics act on the kidney and lead to increased urine output (see Figure 2). An increase in urine excretion in turn leads to a lower plasma volume, which helps lower blood pressure

Add about 12.5J mg of USP Valsartan RS, with J be- .5mg/mL of USP Hydrochlorothiazide RS prepared ing the ratio of the labeled amount (mg) of valsartan as follows. To a suitable amount of the USP Hydro-to the labeled amount (mg) of hydrochlorothiazide chlorothiazide RS in a suitable volumetric flask add per Tablet. Dilute with Diluent to. Qualitative diuretic screen includes: benzthiazide, bumetanide, chlorothiazide, chlorthalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, and metolazone Thiazide diuretics have demonstrated favorable blood pressure lowering efficacy, but the equivalent doses of their more common agents, chlorthalidone and hydrochlorothiazide, are still unclear. Further, concerns exist regarding adverse metabolic effects, which may be attenuated with the concomitant administration of a potassium-sparing diuretic, such as amiloride

Thiazide Diuretic - FPnotebook

Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. It has a role as a xenobiotic, an environmental contaminant, a diuretic and an antihypertensive agent Background on Chlorothiazide. Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Featured Products. Hydrochlorothiazide. Catalog No.:BCC4786. CAS No.:58-93-5. D- (+)-Xylose Drugs that ay cause increased serum chloride levels include: acetazolamide, ammonium chloride, androgens, chlorothiazide cortisone preparations, estrogens, guanethidine, hydrochlorothiazide, methyldopa, and nonsteroidal anti-inflammatory drugs Up-to date list of blood pressure lowering medications by classes, including diuretics, ACE inhibitors, Beta-Blockers, Calcium Channel Blockers, Vasodilators, anti-hypertensive combinations, and other types

PPT - Hypertension as a disease PowerPoint PresentationPpt chapter 51-1Control hypertension o Increases renal excretion ofNURSE-UN 1436 Midterm: PHARM - Exam 1 - Named Drugs - OneClassDiuretic Structures Flashcards at Midwestern University

Due to Diuretic Medicines - Such as Chlorthalidone (Hygroton), Hydrochlorothiazide, or HCTZ (Esidrix, Hydrodiuril, Microzide), Chlorothiazide (Diuril), Indapamide (Lozol), etc. makes kidney patients body to have more sodium, water, and urine to function their kidney properly. But once blood pressure drops, they get started to eat salty foods. Chlorothiazide (Diuril) Hydrochlorothiazide (Esidrix, Hydrodiuril & Microzide) Indapamide (Lozol) Metolazone (Mykrox & Zaroxolyn) Amiloride Hydrochloride (Midamar) This medication increases the maturation of fat cells and increases the conversion of sugar into stored fat — thus reducing systemic blood sugar levels. Weight gain is the main. A dry, irritating cough is the most common adverse effect, but angioedema is the most serious and, if it affects the oropharynx, can be fatal. Angioedema is most common among blacks and smokers. ACE inhibitors may increase serum potassium and creatinine levels, especially in patients with chronic kidney disease and those taking potassium-sparing diuretics, potassium supplements, or. methenamine + hydrochlorothiazide use alternative or monitor urine pH : combo may decr. methenamine efficacy (decreased conversion of methenamine to formaldehyde in alkaline urine Hydrochlorothiazide is a diuretic that can be used alone for treating high blood pressure and edema. It works by blocking sodium and water reabsorption in the kidneys, thereby reducing sodium and water in the body. (Whereas it is clear how hydrochlorothiazide eliminates water from the body,. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate. After oral doses, 10-15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk