Guinea pig lymph node anatomy

Lymphadenitis in Guinea Pigs Lymphadenitis is the clinical term that is used to describe inflammation and swelling of the lymph nodes, which are located throughout the body -- head, neck, limbs, etc. -- and act to spread white blood cells and to filter infectious pathogens and foreign bodies that enter the body Sex difference in the size of the lymph nodes and spleen in guinea-pigs. Sex difference in the size of the lymph nodes and spleen in guinea-pigs Acta Anat (Basel). 1946;1(4):359-64. doi: 10.1159/000140181. Author E ANDREASEN. PMID: 20292298 Spleen / anatomy & histology*. Part of theVeterinary Anatomy Commons for ,the lymph node groups of swine as found in the region of the head, neck and shoulder. Baum's terminology was adopted formed in 1908 on rabbits and guinea pigs. Postma (1928) criticized his own methods of using dead piglets by saying, Howeve ADVERTISEMENTS: In this article we will discuss about the dissection of guinea pig. Also learn about:- 1. The Venous System 2. The Arterial System. The rat and Guinea Pig (Fig. 20.1) belong to the same order Rodentia, class Mammalia. Still, structural differences in the circulatory system (heart, venous and arterial system), to a certain extent [ I. INTRODUCTION. This discussion of gross and microscopic anatomy of the guinea pig (Cavia porcellus) was based upon gross dissection of 10 guinea pigs, euthanatized and perfused with 10% buffered neutral formalin to retain conformation and topographical relationships of internal organs.Six additional animals were similarly perfused prior to preparation of histological materials

This chapter discusses the external anatomy, musculoskeletal system, and behavior of the guinea pigs. The domestic guinea pig is a descendant of the wild cavy (Cavia aperea), which is a common rodent in South America.It is a nonburrowing, herbivorous, crepuscular, hystricomorph (porcupine-like) rodent with a stocky body, short neck and limbs, and with either no tail or a vestigial one Compared to the rabbit, much less is known about the digestive mechanisms of the guinea pig. The guinea pig is is most closely related to another South American rodent, the chinchilla. The guinea pig is a monogastric herbivorous rodent with a large, thin-walled sacculated cecum. The cecum is 15-20.

Inflammation of the Lymph Nodes in Guinea Pigs PetM

Abscesses can form either after a bite from another guinea pig, or if something rough and sharp (e.g., straw) goes through the skin. They can form anywhere on a guinea pig's body, but the most common locations are the head and neck. An abscess in the neck could be a swelling of the lymph node in that area Guinea pigs are susceptible to acute abdomens characterized by gaseous distension (bloat), painful abdomen, anorexia, and profound weakness. Onset appears to be sudden, and the owner may visualize a distended abdomen. Radiographically these individuals have large sections of stomach or cecum distended by gas and sometimes fluid Guinea pigs have an average of 4 young per litter, with a range of 1-13. The young (of both species) are born precocial, meaning they are born fully furred, with eyes open, and overall well developed. Young guinea pigs usually nurse for 21 days, although they can survive on solid food alone after 5 days

Sex difference in the size of the lymph nodes and spleen

  1. ants. Young pigs and ru
  2. Cervical Lymphadenitis (Lumps) Etiology: Streptococcus equi subsp. zooepidemicus is a Gram-positive, beta-hemolytic coccus that is commonly carried in the nasopharynx of guinea pigs. Streptobacillus moniliformis is rarely implicated. Incidence: Infection is rare in laboratory guinea pigs
  3. Characteristics of DiI labeling in left ventricular wall of a control guinea pig heart. A: Photograph of gross specimen showing location of DiI application site (arrow) immediately following placement of the crystals into the myocardium. The ventricular wall just below the tracer was cut through horizontally (arrowhead) to disconnect the lower ventricle from the placement site
  4. Lymphosarcoma is the most common tumor of guinea pigs. It is considered a cancer arising from the blood and is thought to be caused by a retrovirus. Affected guinea pigs often have enlarged lymph nodes in their neck and have a scruffy appearance. As the disease progresses, other lymph nodes become enlarged and the liver and/or spleen may swell
  5. Guinea pig blood components are widely used, and isolated organ preparations such as guinea pig lung and intestine are extensively used in research to develop new medicines. Such tissue and organ preparations were important in the discovery and early development of beta blockers to treat high blood pressure and drugs to treat stomach ulcers
  6. The guinea pig has a stout, compact body and no tail. largely replaced by the use of local lymph node assays in is readily accessible for dissection and exposure 9. Guinea pigs have.
  7. ed in order to study: the morphological features of the stromal stationary reticulum cells with particular regard to recognize their stages of development; the possible ontogenetic.

Lymph Nodes of the Head, Neck and Shoulder Region of Swin

Guinea pigs with visible local or systemic infections, imperfect coat or skin, or that showed signs of stress were rejected, as were those in which the lymph nodes were found to be enlarged ht dissection. The body composition of guinea pigs of the same strain raised under conditions similar to those applied to those used for these experiments i In the guinea pig, a unique S-100 alpha-positive giant dendritic cell (GDC) was found in the subsinusal cortical area. In addition, S-100 immunoreactive lymphocytes were observed in the paracortex-equivalent area of pig nodes. Arterial endothelial cells of the pig and cow were immunoreactive to S-100 beta subunit Lymph Node Diseases. The lymph nodes are part of the lymphatic system. They have several important functions regarding the immune system, and are good indicators of disease. The mammalian body has many internal lymph nodes. These can only be visualized by exploratory surgery, a CT scan, an MRI, a radiograph, or an ultrasound A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring.Mammals get their name from the Latin word mamma, breast.The mammary glands are arranged in organs such as the breasts in primates (for example, humans and chimpanzees), the udder in ruminants (for example, cows, goats, and deer), and the dugs of other animals (for example, dogs and cats) pig-anatomy-and-dissection-guide 1/1 Downloaded from www.epls.fsu.edu on July 8, 2021 by guest [eBooks] Pig Anatomy And Dissection Guide As recognized, adventure as well as experience not quite lesson, amusement, as without difficulty as bargain can be gotten by just checking out a book pig anatomy and dissection guide with it is not directly done, you could resig

The cervical, axillary and inguinal nodes were generally richer in cortex tissue than the pulmonary regional and mesenteric nodes. Histological heterogeneity and medullary sinus dominance were much more evident in the human nodes than in those from animals, except for the guinea pig thoracic node In guinea pig, the Kurloff cells have some characteristics of monocytes and lymphocytes. The first characteristic that Kurloff cells share with monocytes is the presence in the blood and organ but absence from the spleen white pulp, thymus parenchyma, and lymph node follicles Guinea pig popliteal lymph nodes were examined by DNA radioassay and radioautography following the selective labeling of tibial and femoral marrow cells by intramyeloid injections of 3 H‐thymidine. The DNA radioactivity of the node increased for the first four days and at four to seven days exceeded that seen after an intraperitoneal injection of the same total dose of 3 H‐thymidine. It is a South American rodent unrelated to the pig; the name may refer to its shrill squeal. The guinea pig is a small, burrowing rodent that has a compact body. They have rounded bodies, large heads, and blunt noses and reach a length of 6 to 10 in. (15-25 cm) and a weight of 1 to 2 lb (450-900 grams). The guinea pig's rapid reproductive rate.

Dissection of Guinea Pig (With Diagram) Zoolog

possible in the guinea pig, mouse and rat (Magilton and Getty, 1969). Becket et al. (1971) utilized the goat in their investigation on the physiology of the external gen­ italia (penis). Because of increasing value of the goat the present study on the morphology of lymph drainage of the head, neck and thoracic limb, and the thorax, was felt. Pig Anatomy and Terminology. Pigtionary. Involuntary or smooth muscle - Found in the digestive and genital systems and the blood vessel walls. Cardiac muscle - The heart consists largely of this muscle. It is involuntary. Voluntary or skeletal muscle - This is the main muscle mass forming the muscular-skeletal system

What if it's not a trichofolliculoma? High-grade pleomorphic sarcoma with local lymph node metastasis in a guinea pig (Cavia porcellus) A 3-year-old male intact guinea pig (Cavia porcellus) was presented at the clinic with a cutaneous, excoriated mass, in the left axillary region. No additional diagnostics or surgery were accepted by the owner The guinea pig is so widely used in laboratories that it has become synonymous in common speech with experimental animal. But until now there has been no complete and accurate anatomy of this otherwise familiar creature. Cavia has remained uncharted territory for experimenters who come to it without previous experience. Gale Cooper and Alan L. Schiller here provide a thorough description of. 16.16 Guinea pig with enlarged submandibular lymph node. This animal had generalized lymphadenopathy. Lymph node biopsy confirmed the diagnosis of lymphoma. The animal was euthanased four weeks later when it became lethargic and anorexic. (Courtesy of Emma Keeble. INTRODUCTION. The only previous report that humans have a parathymic lymph node (PTLN) was in a study of human fetus thymic lymphatics by Severeanu in 1909. 1 The presence of thymic lymphatics and a thymus‐specific lymph node have been reported in other animals, namely, in sheep 2 and in guinea‐pig. 3 According to these reports, there were various arrangements in the way in which the.

Basophil-rich infiltrates in regional lymph nodes of guinea-pigs were demonstrated by electron microscopy after the intradermal injection of T cell mitogens (PHA and Con A). Basophils infiltrated the stroma of the lymph node via the postcapillary venules (PCV) and migrated to the paracortex. Prior to infiltration of the lymph nodes a cutaneous basophil hypersensitivity reaction was seen in the. Morbid anatomy.?Autopsies have been made on over 100 pigs of all sizes, most of which were killed for examination. The following are the post-mortem findings in a few typical cases: Guinea-pig No. 090. Red and white male; weight, 600 grams; found desad July 10, 1905. Three of the anterior cervical glands are transformed into abscesses 15, 20, 5 The periaortic lymph node group is divided into three subgroups: preaortic, paraaortic, and retroaortic: Dissection. The lateral aortic lymph nodes, in guinea pigs it runs to the left and drains into the left innominate vein. The internal iliac artery is the main artery of the pelvis

Osseous Choristoma of the Ciliary Body in Guinea Pigs J. W. GRIFFITH, J. W. SASSANI, T. A. BOWMAN, AND C. M. LANG The Abyssinian-Hartley guinea pigs were from a closed research colony of approximately 200.5 Two males, each 36 months old, and a female, 42 months old, were killed for research purposes, after blood was collected. Tissues wer An extensive network of lymphatic vessels coming from the thymus of the guinea pig and carrying thymocytes to the general circulation has been demonstrated. 2. Local accumulations or infiltrations of cells at the surface of the lobule or in the interlobular septa have been observed through which thymocytes appear to leave the thymus Guinea Pig Cow Mare Rat Dog Sow Cat; Number of Mammae/teats: 2 2 2 2 4 4 (2 teats) ~10 ~10 8-18 8 Position: Pectoral Pectoral Inguinal Inguinal Inguinal Inguinal Abdominal,Ventral Thoracoabdominoinguinal Thoracoabdominoinguinal Thoracoabdominal Teat Ducts: 10-20 Several 1 1 1 2 1 8-22 2 4- metastasis in the place which, in the guinea pig, is generally occupied by a large lymph node. The ovoid shape of the neoplasm and its lobular structure would suggest the structure of a lymph node. We assume that the tumor cells were carried to this lymph node

The thymus is a specialized primary lymphoid organ of the immune system.Within the thymus, thymus cell lymphocytes or T cells mature. T cells are critical to the adaptive immune system, where the body adapts specifically to foreign invaders.The thymus is located in the upper front part of the chest, in the anterior superior mediastinum, behind the sternum, and in front of the heart Dissection of Brain 7. Dissection of Neck Region 8. Dissection of Urinogenital System 9. The Urinary (Excretory) System 10. Dissection of Genital System. The rat is a typical mammal. Formerly guinea pig (Cavia sp.) (Fig. 19.1) were used for dissection in most of the undergraduate and postgraduate colleges in Indian Universities The other Guideline (406) utilises guinea pig tests, notably the guinea pig maximisation test and the Buehler test (4).. 2. The LLNA provides certain advantages with regard to both scientific progress and animal welfare. It studies the induction phase of skin sensitisation and provides quantitative data suitable for dose response assessment External anatomy of pig. Right lateral right central left central left lateral and caudate. Genital papilla female 7. External anatomy we will start out with the external anatomy of the fetal pig. Part 2 with comparitive human anatomy. Liver the human liver has four lobes. Remove the disk that you cut The dissection of the trigeminal ganglion in the postmortem skull of mini-pigs using an intracranial approach has been illustrated, 14 and an approach via the orbit in newborn pigs has also been described. 15 These publications describe methods that are feasible for harvesting the trigeminal ganglion in routine toxicology studies, where there.

Anatomy - ScienceDirec

Abstract. Lymph node cells were obtained from an inbred strain of Lewis rats injected with guinea pig cord tissue in Freund's adjuvant. These cells, when added to tissue culture monolayers of puppy brain, aggregated on or around the glial elements (1971). The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs. (1972). The regulatory role of macrophages in antigenic stimulation. (1972). Transfer of antigenic macromolecules from macrophages to lymphocytes

The lymphatic system is part of the vascular system and an important part of the immune system, composed of a large network of lymphatic vessels that carry a clear fluid called lymph (from Latin, lympha meaning water ) directionally towards the heart. The lymphatic vessels (or lymph vessels or lymphatics) are thin-walled vessels (tubes) structured like blood vessels, that carry lymph. They. Rosenstreich DL, Blake JT, Rosenthal AS. The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs. J Exp Med. 1971 Nov 1; 134 (5):1170-1186. [PMC free article This new resource provides a basic foundation in small animal anatomy for students of veterinary medicine, animal science, and veterinary technology. Extraordinary accuracy and beautiful original artwork make this a truly unique learning tool that includes the anatomy of all organ systems in the dog, cat, rabbit, rat, and guinea pig - all described in a consistent manner Humans and Pigs may be closer than you think! Both are mammals We share common body systems The anatomy of the pig is close to that of humans The fetal pigs will tell us more about our own bodies and give us a wa Dr. Hana HÜNIGEN (Berlin, Germany): 'Morphometric studies on guinea pig lymph node content of iron oxide contrast agents 6 to 12 weeks after s.c. application'. 1998 Carsten STASZYK (Hannover, Germany): 'Distribution of articular branches of nerves supplying the shoulder and elbow joint capsules in the dog'

The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well-illustrated reference won a 2012 PROSE Award for Best Single Volume Reference in Science from the Association of. Lymph node cells were obtained from an inbred strain of Lewis rats injected with guinea pig cord tissue in Freund's adjuvant. These cells, when added to tissu Heart rate is regulated by the autonomic nervous system but little is known about the pattern of innervation of the pacemaker in the sinoatrial node, or the subpopulations of nerves involved. Therefore in this study the pacemaker was located using electrophysiological methods and the pattern of innervation established by cholinesterase staining Types of local toxicity studies Dermal toxicity studies Dermal photo-toxicity studies Vaginal toxicity studies Rectal tolerance studies Rats & Rabbit Local signs (erythema, oedema), histological examination Guinea pig Used in treatment of leucoderma Examination of erythema & oedema formation Rabbit or Dog Observation of swelling, histopathology. Conrado Alvarenga, Universidade de São Paulo, Urology department, Faculty Member. Studies Body Mass Index, Nonparametric Statistics, and Treatment Outcome

Everyone at Long Beach Animal Hospital loves animals (we will take a picture of you and your pet and post it in our Clients & Pets section if you like) - and it is our mission to provide quality care for pets and exotic pets of all kinds. Call us today at (562) 434-9966 for more information. Call 562-434-9966. Monday - Friday 7:30AM - 10:00PM (5) Basketter, D.A. et al. Interlaboratory evaluation of the local lymph node assay with 25 chemicals and comparison with guinea pig test data. Toxicology Methods 1:30-43 (1991). (6) Buehler, E.V. Delayed contact hypersensitivity in the guinea pig, Archives of Dermatology 91:171-177 (1965) Professionals with more advanced knowledge will find the atlas useful in explaining anatomy to laypersons, clients, and students. - Doody's Reviews, June 2009 The Color Atlas of Small Animal Anatomy: The Essentials beautifully depicts the topographic anatomy of organ systems in dogs, cats, rabbits, rats, and guinea pigs.... The atlas is an.

Cellular renewal in the enamel organ and the odontoblast layer of the rat incisor as followed by radioautography using 3 H‐thymidine. C. E. Smith. H. Warshawsky. Pages: 523-561. First Published: 01 December 1975 Lung tumors are relatively rare in dogs, accounting for only 1% of all cancers diagnosed. The average age at diagnosis is 10 years with no sex or breed predilection. Metastatic cancer to the lungs is much more common than primary lung cancer. Lung tumors have moderate to high potential for metastasis (spreading) Shifting Away from Chemotherapy. Dr. Kerry Rogers, a CLL specialist at Ohio State's The James Cancer Center, says the first thing to acknowledge is the median age of patients diagnosed with CLL - those in their mid-60s or almost 70. This means there may be other factors impacting their overall health The importance of exercise for guinea pigs. Learn more about exercising tips for raising a healthy and happy guinea pig by creating new ways to keep them active and occupied. Read More. Health & Wellness. Routine exams for ferrets. Read more about vaccinations and routine exams for your pet ferret to keep your pet in good, healthy condition.

Guinea Pig. The guinea pig (GP) or cavy, Cavia porcellus, is the domesticated form of a rodent found in the wild in South America. There are three basic breeds: shorthair or English cavy has short hair; Abyssinian cavy has short rough hair formed in whorls or rosettes; and peruvian cavy has long hair often exceeding 6 inches in length In the cow and pig however the reverse is true and division is far more caudal resulting in the vaginal artery actually being a branch of the internal iliac. Lymphatic Drainage. Iliosacral lymph nodes; Alternative Anatomical Thinkin

Cisterna chyli - Wikipedia

Cutaneous Mast Cell Tumors in Dogs What are mast cell tumors? Mast cell tumors are among the most commonly reported canine skin tumors. While any dog may develop a mast cell tumor, there are certain breeds who are predisposed including English Bulldogs, Boxers, Pugs and retrievers Lymph nodes, rich in B and T white blood cells, function as a filtration system for waste products, bacteria, foreign objects, damaged or abnormal cells, and helping to fight infections. Serving as a key part in the diagnosis and treatment of many types of cancers, researchers study the lymphatic system to aid in the ongoing fight against cancer

Anatomy, Physiology, and Behavior - ScienceDirec

In the guinea pig, the thymus is located in the upper ventral part of the neck, and its efferent lymphatic vessels enter the cervical lymph duct that descends towards the cervical lymph nodes. Through a midline incision in the neck under ether anesthesia, the cervical lymph nodes on both sides were exposed by blunt dissection Cervical lymph nodes are a characteristic location for abscesses due to S. zooepidemicus (Lancefield Group C). Inoculation is usually the result of oral abrasions with contamination. Most guinea pigs harbor the organism in the nasopharynx. 34 Cervical lymph nodes Cavian leukemia Cervical node lymphom

lymph nodes, except for those of pigs, is that blood enters the lymph nodes through one or more arteries at the hilus, a single indentation in the medulla. 3) This view has been supported by observations in dogs, 14) guinea-pigs, 6) rabbits15) and rats. 2 Using gross dissection of the thoracic cavity of ten guinea pigs, this study aims to achieve a detailed description of the heart topography and pericardial ligaments in guinea pigs. Occupying the majority of the narrow thoracic cavity, in the middle mediastinum, in guinea pigs, like all mammals, heart is double layer coated by the pericardium

These studies suggest that in mice and guinea pigs, once Mtb enters the lymph node, the host is unable to eliminate it, making the lymph node a bacterial reservoir. Studying Mtb bacterial dynamics in human lymph nodes is extremely difficult since the timing of Mtb infection is usually unknown and thoracic lymph node biopsies are invasive Abstract. The guinea pig, or cavy, has been widely used in the fields of microbiology, immunology, and dermatology. Its use in these fields is related to its susceptibility to a wide range of microorganisms by inoculation, to the facility with which it responds to immunogens with antibody and cell-mediated responses, and to the similarity of response of guinea pig skin and human skin for. The sub-mandibular and prescapular lymph node (LN) regions can be palpated, but the LNs are usually only detected if there is a local or generalised lymphadenopathy. The popliteal LNs are Understanding of the anatomy of the abdominal cavity is crucial to interpreting the results of manual palpation. Adopting a systematic approach, working. Chinchillas and other hystricognath rodents (eg, guinea pigs, degus, tuco-tucos) are unusual in that their insulins exhibit a very low biologic potency relative to pig insulin, yet the receptor-binding affinity is significantly higher, indicating that the efficacy of their insulin on receptors is ~2-fold lower than that of pig insulin

Guinea pig bloat occurs when gas builds up in your pet's gastrointestinal intestinal tract. Guinea pigs are not able to pass gas through their intestines, so the gas just stays in the intestines and produces severe pain, says Lori Hageman, DVM, owner of Ark Pet Hospital in Antioch, Calif. Guinea pig bloat can be fatal if untreated. A guinea pig of healthy weight should feel firm in the body and weigh about 2 pounds. An overweight guinea pig will feel soft. Sometimes, though, a guinea pig will have a bloated belly for other reasons, such as worms or, rarely, a tumor. Don't take chances. Watch your cavy's diet and see your vet adult male guinea pigs (400-500 g). An animal was anesthetized with ketamine (100 mg/kg), xylazine (20 mg/kg), and pentobarbital (50 mg/ kg) and then perfused with 2% paraformaldehyde plus 2% glutaralde-hyde in 0.1 M phosphate buffer. Tissue was stored overnight at 4°C and then dissected, osmicated, soaked in uranyl acetate, and prepared fo Basically this disease entails lumps; the guinea pig's lymph nodes become very large and develop abscesses (a collection of pus). A strange disease for the guinea pigs is Pododermatitis which is also known as 'bumblefoot.' This occurs in guinea pigs that live on wire floors that are unsanitized and rough

Common Problems in Guinea Pigs - ACVC2001 - VI

Lymph nodes should be small, soft and non-painful. If a lymph node is hard, hot, or painful then a concern about that region of the body is developed. The common locations for the peripheral lymph nodes are the cervical nodes under the back of the jaw, the pre-scapular which are between the shoulder and the neck BALT is not a constitutive structure in all these species. Its frequency varies widely, from 100% in rabbits and rats, 50% in guinea pigs, 33% in pigs, to its absence in cats and all normal human lungs. BALT seems to be a lymphoid structure which is not present in all the species studied but can develop in the lung after stimulation

How to Diagnose Lumps in Guinea Pigs: 11 Steps (with Pictures

The source of fatty acids incorporated into proliferating lymphoid cells in immune-stimulated lymph nodes - Volume 89 Issue 3 - Caroline M. Pond, Christine A. Mattack Special anatomy is summarized as brief data in tables of muscles, lymph nodes, and nerves, with references to the corresponding pages in the text. Comparative anatomy is addressed through references to the horse and dog. In addition the text-atlas is intended to provide a valuable introduction to the Anatomy of the Living Animal Kurkowski R., Kummer W. & Heym C. Substance P-immunoreactive nerve fibers in tracheobronchial lymph nodes of the guinea pig: origin, ultrastructure and coexistence with other peptides. Peptides 11. The guinea pig may present with swelling or abscesses of the cervical lymph nodes. The infection may be a result of bite wounds, 2 but abrasions to the oral mucosa caused by malocclusion or coarse feed products may contribute to the problem. 7 Treatment options include surgical excision of the affected nodes, draining the purulent material from.

centration of the lymph node cells was then adjusted to the number desired and the material used immediately in the tissue culture system. Cells obtained from rats injected with guinea pig cord tissue and adjuvants will be referre Currently, the only validated methods to identify skin sensitization effects are in vivo models, such as the local lymph node assay (LLNA) and guinea pig studies. There is a tremendous need, in particular due to novel legislation, to develop animal alternatives, for eaxample, quantitative structure−activity relationship (QSAR) models. Here, QSAR models for skin sensitization using LLNA data.

Popesko Atlas Anatomy guinea lynx eyes, anatomie en fysiologie caviadokter com, anatomy and nomenclature of murine lymph nodes, guinea lynx eyes, anatomy and nomenclature of murine lymph nodes, anatomie en fysiologie caviadokter comeye discharge normal guinea pigs excrete a milky white liquid which lubricate Department of Anatomy and Cell Biology, Medical University of South Carolina, Charleston, New Haven, Connecticut Mice were immunized with human intrinsic factor, and their lymph node cells were fused with a my eloma cell line hy standard hyhridoma techniques. (17). Briefly, guinea pig brush border membrane prepara- tions were incubated. LYMPH NODE FOLLICLES IN THE DOG A.C. Salvador, A.S. Pereira, N.R. Grande (rats, mice, and guinea pigs) and sheep where these arteries apparently end at the LF periphery (4-8). To pursue this subject further, we investigated the vascular anatomy of the LF in dogs. We used anatomical methods that allowed correlatio The Guinea Pig Maximisation Test, Journal of Investigative Dermatology 52 (1969): 268-276. 6 G.F. Gerberick et al., Local Lymph Node Assay (LLNA) for Detection of Sensitization Capacity of Chemicals, Methods 41 (2007): 54-60